Health
Possible link between weight-loss injections and gallbladder removals
In the previous year, operations saw a 15% yearly rise, prompting surgeons to call for additional research.
Specialist doctors are calling for further investigation into a potential connection between weight-loss injections and a rise in gallbladder removals, citing the need for more research to understand the relationship between the two.

According to data from NHS England, the number of gallbladder surgeries performed in 2024-25 reached a decade-high, with a notable increase in procedures compared to previous years.
Ahmed Ahmed, president of the British Obesity and Metabolic Specialist Society, has observed a correlation between weight-loss injections and gallbladder removals, with an increasing number of patients reporting the use of such injections prior to surgery.
The UK's medical licensing body acknowledges that gallstones are a known side effect of weight-loss injections, and the agency continues to monitor the situation closely.
The Medicines and Healthcare products Regulatory Agency (MHRA) recently updated its guidance on GLP-1 injections, such as Wegovy, to reflect the risk of acute pancreatitis, which is often associated with gallstones.
Manufacturers of weight-loss injections, including Mounjaro, Wegovy, and Saxenda, emphasize their commitment to patient safety and encourage the reporting of any adverse reactions to their products.
Ahmed, a consultant surgeon, notes that the relationship between weight-loss injections and gallstones is not yet fully understood, and it is unclear whether the injections themselves or the resulting rapid weight loss are the primary cause of the increased risk.
Ahmed stresses the need for further research to determine whether there is a causal link between weight-loss injections and gallstones.
Researchers at University College London estimate that approximately 1.6 million UK adults have used weight-loss injections in the past year, primarily obtained through private prescriptions rather than the NHS.
While many users have reported positive experiences with weight-loss injections, some have experienced complications, including gallstones.
Sue Peacock, a mother of five from Wirral, Merseyside, shares her experience of becoming severely unwell after using Mounjaro, which ultimately led to the diagnosis of gallstones and the need for gallbladder removal.
Peacock initially considered using Mounjaro after consulting with her GP, but soon found herself diagnosed with gallstones, which later caused pancreatitis, a potentially life-threatening condition.
Prior to undergoing surgery, Peacock's gallstones caused pancreatitis, resulting in severe pain and breathing difficulties.

She describes the experience as "life-changing" and extremely frightening, with her children constantly worried about her health.
Peacock believes that the weight-loss injections were the cause of her illness and has been left with a lasting impact on her life.
Peacock had no prior health issues before using the injections and is convinced that they triggered her subsequent health problems.
The experience has had a profound effect on Peacock, making her more aware of her own mortality and the potential risks associated with certain medical treatments.
Peacock's story highlights the importance of carefully considering the potential risks and benefits of weight-loss injections, as well as the need for ongoing monitoring and support.
Wegovy and Saxenda were approved for weight loss in the UK in 2021, while Mounjaro received approval in 2023.
NHS England data shows that the number of gallbladder operations increased by 15% in 2024-25, with 80,196 procedures performed, marking the highest number in the past decade.
Patient information leaflets for weight-loss injections warn of the risk of gallstones, which can affect up to 1 in 100 users, according to clinical trial data.
Rapid weight loss, whether achieved through severe diets or other means, is known to increase the risk of developing gallstones.
Certain demographics, including women, individuals over 40, and those living with obesity, are more likely to develop gallstones, according to NHS guidelines.
Ahmed acknowledges that the current data does not provide a clear understanding of the relationship between weight-loss injections and gallstones, highlighting the need for further research.
Ahmed is calling for a trial to compare the effectiveness and safety of weight-loss injections with bariatric surgery, which involves restricting stomach size to reduce appetite.

Such a study would provide valuable insights into the clinical and cost-effectiveness of these treatments, ultimately informing better decision-making for patients and healthcare professionals.
James Hewes, a Bristol-based consultant surgeon specializing in obesity and bariatric surgery, recognizes the transformative impact of weight-loss injections on obesity management.

However, Hewes, like Ahmed, emphasizes the need for more research into the long-term effects of these treatments to ensure their safe and effective use.
Hewes notes an increase in patients presenting with gallstones, although it is often difficult to determine whether the condition is directly related to the use of weight-loss injections.
The complexity of this issue highlights the importance of careful patient assessment and monitoring to minimize potential risks.
For many individuals, weight-loss injections have been a positive and effective treatment option, leading to significant weight loss and improved overall health.

Steve O'Farrell, a 67-year-old grandfather from Bristol, credits Mounjaro with helping him achieve lasting weight loss and improved energy levels, allowing him to exercise regularly for the first time in years.
O'Farrell acknowledges the potential risks associated with weight-loss injections, including gallstones, but believes that the benefits outweigh the risks in his case.
He emphasizes the importance of informed decision-making, encouraging individuals to carefully weigh the pros and cons of these treatments before starting them.
O'Farrell's experience highlights the need for personalized approaches to weight loss, taking into account individual circumstances and health status.
The NHS emphasizes that gallbladder removal is a common and generally safe procedure, although as with any surgery, there are risks involved, such as blood clots or infection.
Hewes advises individuals considering weight-loss treatments to aim for gradual and controlled weight loss to minimize the risk of developing gallstones.
Both Ahmed and Hewes stress the importance of open communication between patients and healthcare professionals, ensuring that individuals are fully informed about the potential benefits and risks of weight-loss injections.

Manufacturers of weight-loss injections, including Eli Lilly and Novo Nordisk, encourage patients to report any side effects or concerns to their healthcare providers, emphasizing the importance of patient safety and well-being.
By prioritizing patient safety and promoting informed decision-making, healthcare professionals and manufacturers can work together to optimize the use of weight-loss injections and minimize potential risks.
According to Novo Nordisk, individuals who encounter adverse reactions are encouraged to notify their healthcare provider and submit a report to the MHRA's Yellow Card scheme, a system established to facilitate the prompt identification of safety concerns.
This report was supplemented by additional research from Ema Sabljak of the BBC England Data Unit.
For those wishing to reach out to the BBC regarding this story, the dedicated email address is westinvestigations@bbc.co.uk.
To stay updated, follow BBC West on social media platforms such as Facebook, X, and Instagram, or share story suggestions via WhatsApp at 0800 313 4630.
Health
Study Explores if Brain Stimulation Can Reduce Selfish Behavior
Researchers have found a way to temporarily and marginally decrease self-centered behavior in individuals by activating two specific regions of the brain.
Researchers have made a groundbreaking discovery, finding that temporary reductions in selfish behavior can be achieved by stimulating specific areas of the brain.

A recent study conducted at the University of Zurich involved 44 participants who were tasked with dividing a sum of money between themselves and an anonymous partner, allowing scientists to observe their decision-making processes.
The experiment utilized electrical current to stimulate the frontal and parietal regions of the brain, located at the front and rear of the skull, respectively. When these areas were stimulated simultaneously, participants exhibited a greater willingness to share their funds.
According to Prof Christian Ruff, a lead author of the study, the observed effects were consistent, albeit modest in scale.
Statistical analysis revealed a notable increase in participants' willingness to allocate funds to others, indicating a shift in their behavior.
The findings not only provide insight into the neural mechanisms underlying fundamental human behavior but may also have implications for the treatment of certain brain disorders characterized by impaired social behavior.
Prof Ruff noted that some individuals struggle with profound social difficulties due to an inability to consider others' perspectives, leading to consistently selfish behavior, and suggested that this discovery could potentially be used to address such issues.
However, the effects of the brain stimulation were found to be short-lived, suggesting that repeated application may be necessary to achieve lasting changes.
Prof Ruff likened the potential effects of repeated stimulation to the benefits of regular exercise, stating that consistent application over a prolonged period could lead to significant changes in behavior, much like the physical adaptations that occur with regular gym attendance.
This latest discovery builds upon a previous study in which researchers monitored brain activity while participants engaged in a similar money-sharing game, providing a foundation for the current findings.

The earlier study identified two brain regions that appeared to be synchronized, with neural activity occurring at the same frequency, when participants made more generous decisions.
These brain areas are known to play a crucial role in decision-making and empathy, enabling individuals to distinguish between their own feelings and those of others.
When participants made selfless decisions, the regions responsible for empathy and decision-making were found to be communicating with each other.
The researchers sought to investigate whether electrical stimulation could be used to influence this communication and promote more selfless decision-making.
One participant who underwent the brain stimulation test described the experience as a gentle, soothing sensation, comparable to a warm shower or light rain on the scalp.
The participant reported making decisions while receiving the stimulation without feeling any external influence on their choices.
The discovery of a consistent neural pattern associated with selfless decision-making across multiple individuals suggests that altruism may be an innate, evolutionarily conserved trait that enables humans to care for one another.
Prof Ruff emphasized the clinical significance of this finding, highlighting the potential to modify and influence this neural mechanism.
Dr Jie Hu, a co-author of the study, noted that the research provides evidence of a causal relationship between brain activity and decision-making, demonstrating that targeted stimulation can alter an individual's sharing behavior.
By manipulating communication within a specific brain network using non-invasive stimulation, the researchers observed a shift in participants' decisions, influencing the balance between self-interest and altruism.
Addressing concerns about the potential implications of this research, Prof Ruff assured that the experiment was conducted with strict adherence to medical regulations and ethical guidelines, ensuring the well-being and informed consent of all participants.
The neuroscientist drew a distinction between the controlled, medically regulated nature of the experiment and the often-subliminal influences of social media and advertising, which can affect behavior without explicit consent.
Prof Ruff suggested that, in contrast to the experiment, the impacts of social media and advertising on brain function and behavior are often unforeseen and uncontrolled, highlighting the importance of careful consideration and regulation in such contexts.
Health
NHS Workers to Receive 3.3% Pay Increase
Labor unions have expressed displeasure, yet the government maintains that its actions showcase a dedication to its workforce.
The government has confirmed that NHS staff in England will receive a 3.3% pay increase in the upcoming financial year.

This pay award applies to approximately 1.4 million health workers, including nurses, midwives, physiotherapists, and porters, but excludes doctors, dentists, and senior management.
Although the Department of Health and Social Care initially proposed a lower figure, it has accepted the recommendation of the independent pay review body to demonstrate its commitment to NHS staff, resulting in a higher pay rise than initially suggested.
However, several health unions have expressed disappointment with the announced pay award.
Prof Nicola Ranger, general secretary of the Royal College of Nursing (RCN), noted that the 3.3% increase falls short of the current consumer price index (CPI) inflation rate of 3.4%, which measures the rise in prices over the past year.
Prof Ranger stated, "A pay award that is lower than the current inflation rate is unacceptable, and unless inflation decreases, the government will be imposing a real pay cut on NHS workers."
She criticized the government's approach, saying, "This strategy of making last-minute decisions is not an appropriate way to treat individuals who are essential to a system in crisis."
Prof Ranger indicated that she would wait to see the pay awards for the rest of the public sector and doctors before deciding on a course of action.
The RCN had previously reacted strongly to the 5.4% pay increase received by resident doctors last year, compared to the 3.6% increase received by nurses, which they described as "grotesque".
Prof Ranger emphasized, "Nursing staff will not accept being treated with disrespect, as has happened in the past when they were given lower pay awards than other groups."
Helga Pile, head of health at Unison, the largest health union, commented, "NHS staff who are already under financial pressure will be outraged by another pay award that fails to keep up with inflation."
"Once again, they are expected to deliver more while their pay effectively decreases, as it falls behind the rising cost of living," she added.
In response, the government argued that the pay award is actually above the forecasted inflation rate for the coming year, which is around 2%.
A spokesperson for the Department of Health and Social Care stated, "This government greatly values the outstanding work of NHS staff and is committed to supporting them."
The pay increase is expected to be implemented by the start of April.
However, the government did not provide a timeline for the announcement on doctors' pay, as the pay review body responsible for making recommendations on their pay has yet to submit its report to ministers.
The government is currently engaged in negotiations with the British Medical Association regarding the pay of resident doctors, previously known as junior doctors.
Members of the BMA recently voted in favor of strike action, granting them a six-month mandate for walkouts, and there have been 14 strikes so far in the ongoing dispute.
Health
NHS Waiting List Hits Three-Year Low
In England, the backlog has fallen below 7.3 million for the first time since 2023, yet worries persist regarding prolonged waiting times in accident and emergency departments.
England's hospital waiting list has reached its lowest point in almost three years, marking a significant milestone in the country's healthcare system.

As of December 2025, the number of patients awaiting treatment, including knee and hip operations, stood at 7.29 million, the lowest figure recorded since February 2023.
However, the latest monthly update from NHS England reveals that long wait times persist in Accident and Emergency departments, with a record number of patients experiencing 12-hour trolley waits.
In January 2026, over 71,500 patients spent more than 12 hours waiting for a hospital bed after being assessed by A&E staff, the highest number tracked since 2010.
This translates to nearly one in five patients admitted after visiting A&E waiting for an extended period.
According to Health Secretary Wes Streeting, while progress has been made, significant challenges still need to be addressed.
Streeting acknowledged that "there is much more to do" and emphasized the need to accelerate progress, but expressed optimism that the NHS is on the path to recovery.
Dr. Vicky Price, representing the Society for Acute Medicine, noted that hospitals are operating beyond safe capacity in terms of emergency care.
Dr. Price highlighted the vulnerability of patients who require admission, often elderly and frail individuals with complex needs, who are at greater risk of harm when care is delivered in corridors and hospitals exceed safe limits.
Duncan Burton, Chief Nursing Officer for England, commended the progress made in reducing wait times, achieved despite the challenges posed by strikes by resident doctors.
Burton attributed this progress to the hard work and dedication of NHS staff, describing it as a "triumph".
Although the waiting list decreased, performance against the 18-week target slightly declined, with 61.5% of patients waiting less than 18 weeks, compared to 61.8% in November, and still short of the 92% target set to be met by 2029.
Rory Deighton of the NHS Confederation, which represents hospitals, welcomed the progress but cautioned that it obscures significant regional variations.
A recent BBC report revealed that nearly a quarter of hospital trusts experienced worsening wait times over the past year.
Deighton emphasized that the NHS is composed of numerous separate organizations, each with unique financial and operational challenges, making it more difficult to address care backlogs in some areas.
According to Deighton, this means that tackling care backlogs will be more challenging in certain parts of the country due to these distinct regional challenges.
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